Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts

IntroductionBurkitt Lymphoma (BL), an aggressive B-cell lymphoma driven by MYC translocations, requires intensive chemotherapy treatments which deliver high effectiveness yet increase future risks of developing secondary malignancies. We have previously shown that DDX3X, an RNA helicase frequently m...

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Detalhes bibliográficos

Principais autores:	Hugues Beauchemin, Zeinab Dalloul, Eva-Maria Piskor, Virginie Calderon, Andrew Chatr-aryamontri, Thierry Bertomeu, Tarik Möröy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-07-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	RNA helicase DDX3 as a potential target Burkitt lymphoma (BL) DDX3 inhibitor xenograft ATP-dependent RNA helicase
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1642006/full
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