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Development of an ostrich-derived single-chain variable fragment (scFv) against PTPRN extracellular domain

Abstract In type 1 diabetes, the immune system destroys pancreatic beta cells in an autoimmune condition. To overcome this disease, a specific monoclonal antibody that binds to pancreatic beta cells could be used for targeted immunotherapy. Protein tyrosine phosphatase receptor N (PTPRN) is one of t...

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Bibliografiska uppgifter
Huvudupphov: Hamed Dabiri, Majid Sadeghizadeh, Vahab Ziaei, Zahra Moghadasi, Ali Maham, Ensiyeh Hajizadeh-Saffar, Mahdi Habibi-Anbouhi
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2024-02-01
Serie:Scientific Reports
Länkar:https://doi.org/10.1038/s41598-024-53386-5
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