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Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies

Protein-based targeted toxins play an increasingly important role in targeted tumor therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major reason for this is the limited entry of the toxin into the cytosol of the target cell, which is required to mediat...

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Principais autores: Hendrik Fuchs, Nicole Niesler, Alexandra Trautner, Simko Sama, Gerold Jerz, Hossein Panjideh, Alexander Weng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-03-01
coleção:Biomedicines
Assuntos:
saponins
endosomal escape
efficacy enhancers
targeted toxins
immunotoxins
cytosolic drug delivery
controlled drug release
cancer treatment
endocytosis
Acesso em linha:http://www.mdpi.com/2227-9059/5/2/14
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