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Microgravity-driven Rab27B activation amplifies mesenchymal stem cell-derived extracellular vesicle production and functions

Abstract Background Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as promising treatments for immunomodulation and tissue regeneration. However, the scalable production of functionally enhanced EVs remains a critical challenge. This study introduces microgravity culture...

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Principais autores: Yi Ding, Yiru Fu, Meng Sun, Yue Li, Ang Li, Ye Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:Stem Cell Research & Therapy
Fag:
Extracellular vesicles
Microgravity
Rab27B
Immunomodulatory
Tissue repair and regeneration
Online adgang:https://doi.org/10.1186/s13287-025-04711-w
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