Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy

Abstract T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological memory, and long-term control of pathogens. In response to strong stimulation, as seen in severe or chronic infections or cancer, T cells acquire...

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Hlavní autoři:	Yannick Bulliard, Borje S. Andersson, Mehmet A. Baysal, Jason Damiano, Apostolia M. Tsimberidou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-10-01
Edice:	Journal of Hematology & Oncology
Témata:	Differentiation Exhaustion Memory T cell CAR-T
On-line přístup:	https://doi.org/10.1186/s13045-023-01504-7
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