Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing

RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2. KPAP1 is the primary polymerase that adds adenines (As)...

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Detalles Bibliográficos

Principais autores:	Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-01-01
Series:	Frontiers in Parasitology
Assuntos:	African trypanosomiasis nucleotidyltransferases site-directed mutagenesis mRNA tails non-coding RNA arginine methylation
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fpara.2023.1298561/full
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