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Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing

RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2. KPAP1 is the primary polymerase that adds adenines (As)...

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Principais autores: Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-01-01
Serier:Frontiers in Parasitology
Fag:
African trypanosomiasis
nucleotidyltransferases
site-directed mutagenesis
mRNA tails
non-coding RNA
arginine methylation
Online adgang:https://www.frontiersin.org/articles/10.3389/fpara.2023.1298561/full
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