SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

Abstract Objective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and pyroptosis of FLS plays a key role in those pathological processes durin...

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Hlavní autoři:	Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun, Youhua Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-08-01
Edice:	Arthritis Research & Therapy
Témata:	SMAD2 Pyroptosis Rheumatoid arthritis TGF-β Fibroblast-like synoviocytes
On-line přístup:	https://doi.org/10.1186/s13075-023-03136-1
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