Engineered LINC MIR503HG-loaded extracellular vesicles maintain stemness and pluripotency during long-term hiPSCs culture

The reduction of stemness and pluripotency during the prolonged culture of hiPSCs poses a significant challenge in regenerative medicine. This study identified LINC MIR503HG as a factor involved in maintaining hiPSCs stemness. Consequently, it developed a highly efficient delivery system based on AD...

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Detalhes bibliográficos

Principais autores:	Jiaqi Zhu, Xiaoren Zhu, Wei Feng, Yi Jin, Xinqi Ge, Yuxi Li, Xiaoxia Xue, Zhiwei Wang, Yang Xu, Yan Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2026-04-01
coleção:	Bioactive Materials
Assuntos:	Human induced pluripotent stem cells Long non-coding RNAs Extracellular vesicles Stem cell stemness Differentiation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452199X25006152
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