Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk

Although the biochemical and pathological hallmarks of Alzheimer’s disease (AD), such as axonal transport defects, synaptic loss, and selective neuronal death, are well characterized, the underlying mechanisms that cause AD are largely unknown, thereby making it difficult to design effective therape...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Sreedevi Raman, Nicholas Brookhouser, David A. Brafman
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2020-05-01
Σειρά:	Neurobiology of Disease
Θέματα:	Alzheimer’s disease Pluripotent stem cells Apolipoprotein E Gene editing Organoids
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S0969996120300632
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