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Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Abstract Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-dop...

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Principais autores: Jiachen Shi, Qiuling Ma, Wenting Su, Congyan Liu, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xi Jiang, Chang Ge, Fei Kong, Yan Chen, Ding Qu
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science (AAAS) 2023-05-01
Serier:Biomaterials Research
Fag:
Dissolving microneedles
Melanoma
Cannabidiol
Effervescent
Tumor microenvironment
Ca2+ influx
Online adgang:https://doi.org/10.1186/s40824-023-00390-x
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