Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Abstract Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-dop...

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Autori principali:	Jiachen Shi, Qiuling Ma, Wenting Su, Congyan Liu, Huangqin Zhang, Yuping Liu, Xiaoqi Li, Xi Jiang, Chang Ge, Fei Kong, Yan Chen, Ding Qu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Association for the Advancement of Science (AAAS) 2023-05-01
Serie:	Biomaterials Research
Soggetti:	Dissolving microneedles Melanoma Cannabidiol Effervescent Tumor microenvironment Ca2+ influx
Accesso online:	https://doi.org/10.1186/s40824-023-00390-x
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