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Changes in H+, K+, and Ca2+ Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels

Acid-sensing ion channels (ASICs) are activated by extracellular acidification. Because ASIC currents are transient, these channels appear to be ideal sensors for detecting the onset of rapid pH changes. ASICs are involved in neuronal death after ischemic stroke, and in the sensation of inflammatory...

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Principais autores: Omar Alijevic, Zhong Peng, Stephan Kellenberger
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-10-01
Serier:Frontiers in Cellular Neuroscience
Fag:
ASIC
acidification
action potential
neuronal signaling
modification of gating by ions
calcium
Online adgang:https://www.frontiersin.org/articles/10.3389/fncel.2021.732869/full
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