Changes in H+, K+, and Ca2+ Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels

Acid-sensing ion channels (ASICs) are activated by extracellular acidification. Because ASIC currents are transient, these channels appear to be ideal sensors for detecting the onset of rapid pH changes. ASICs are involved in neuronal death after ischemic stroke, and in the sensation of inflammatory...

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Автори:	Omar Alijevic, Zhong Peng, Stephan Kellenberger
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2021-10-01
Серія:	Frontiers in Cellular Neuroscience
Предмети:	ASIC acidification action potential neuronal signaling modification of gating by ions calcium
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fncel.2021.732869/full
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