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X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies

Abstract Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males. Genes can escape this silencing, potentially leading to sex-based differences in disease. Results Across t...

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Principais autores: Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:BMC Genomics
Fag:
Chromosome X
Dosage compensation
Escape
Gene expression
Inactivation
Online adgang:https://doi.org/10.1186/s12864-025-12352-9
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