X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies

Abstract Background X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males. Genes can escape this silencing, potentially leading to sex-based differences in disease. Results Across t...

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Autors principals:	Daniel Shriner, Ayo P. Doumatey, Lin Lei, Mateus H. Gouveia, Karlijn A. C. Meeks, Elisabeth F. Heuston, Jie Zhou, Adebowale A. Adeyemo, Charles N. Rotimi
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-11-01
Col·lecció:	BMC Genomics
Matèries:	Chromosome X Dosage compensation Escape Gene expression Inactivation
Accés en línia:	https://doi.org/10.1186/s12864-025-12352-9
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