A derivative of PD156707 selectively inhibits NLRP3 inflammasome activation by directly binding to NLRP3

Abstract The NLRP3 inflammasome is a central driver of inflammatory pathology, yet clinical translation of small-molecule inhibitors remains limited by selectivity and safety. Through a 3000-compound screen, we identified PD-156707 as an apparent inhibitor of NLRP3 signaling; however, activity was n...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ye-Rin Jung, Xiang Fei, Hyeong-Min Lee, Anamul Hasan, Eun-Ji Kim, Kyu Tae Byun, Seung-Yong Seo, Tae-Bong Kang, Kwang-Ho Lee
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	NLRP3 inflammasome Small-molecule inhibitor DPD (PD-156707 derivative)
Online-Zugang:	https://doi.org/10.1038/s41598-026-49619-4
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