Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting in pyroptosis. The multi-protein composition of...

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Autors principals:	Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma, Mukut Sharma
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-04-01
Col·lecció:	European Journal of Medicinal Chemistry Reports
Matèries:	NLRP3 inflammasome Sulfonylureas Michael acceptors Chalcone NLRP3 inhibitors
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2772417422000723
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