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Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting in pyroptosis. The multi-protein composition of...

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Principais autores: Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma, Mukut Sharma
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-04-01
coleção:European Journal of Medicinal Chemistry Reports
Assuntos:
NLRP3 inflammasome
Sulfonylureas
Michael acceptors
Chalcone
NLRP3 inhibitors
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2772417422000723
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