Structure matters: commensal Phocaeicola vulgatus lipopolysaccharide induces attenuated microglial activation and preserves neuronal integrity

Lipopolysaccharides (LPSs) from Gram-negative bacteria are widely used to model neuroinflammation in vitro and in vivo. However, this paradigm assumes that all LPS chemotypes are uniformly pro-inflammatory, despite significant structural diversity between enterobacterial pathogens and gut-resident c...

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Autores principales:	Valentina Mazziotti, Luca De Simone Carone, Francesca Olmeo, Fabrizio Chiodo, Alba Silipo, Antonio Molinaro, Flaviana Di Lorenzo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-04-01
Colección:	Frontiers in Cellular Neuroscience
Materias:	gut-brain axis lipopolysaccharide (LPS) Microglia neuroinflammation Phocaeicola vulgatus
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fncel.2026.1796397/full
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