Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

IntroductionSepsis is responsible for 1 in 5 deaths globally and the majority of those who survive have lasting health issues. A hallmark of sepsis is a deregulated inflammatory response to infection, with leukocytes playing a critical role.MethodsThis study utilised a targeted single-cell multi-omi...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Joshua Flynn, Anne Marie Baird, Eamon Breen, Michael Carty, Ciara S. McNevin, Lisa McDermott, Elaine M. Kenny, John Davis Coakley, Thomas Ryan, Derek G. Doherty, Orla Sheils
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2025-10-01
Saila:	Frontiers in Immunology
Gaiak:	sepsis multi-omic single-cell sequencing immunosuppression cytotoxicity inflammation
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1667186/full
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!