Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

IntroductionSepsis is responsible for 1 in 5 deaths globally and the majority of those who survive have lasting health issues. A hallmark of sepsis is a deregulated inflammatory response to infection, with leukocytes playing a critical role.MethodsThis study utilised a targeted single-cell multi-omi...

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Detaylı Bibliyografya
Asıl Yazarlar:	Joshua Flynn, Anne Marie Baird, Eamon Breen, Michael Carty, Ciara S. McNevin, Lisa McDermott, Elaine M. Kenny, John Davis Coakley, Thomas Ryan, Derek G. Doherty, Orla Sheils
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2025-10-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	sepsis multi-omic single-cell sequencing immunosuppression cytotoxicity inflammation
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1667186/full
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Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

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