The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency

ABSTRACT HIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual proviruses away from active transcription unit...

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Bibliografiska uppgifter

Huvudupphov:	Anne Bruggemans, Gerlinde Vansant, Eline Pellaers, Paulien Van de Velde, Frauke Christ, Zeger Debyser
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	American Society for Microbiology 2026-06-01
Serie:	Microbiology Spectrum
Ämnen:	HIV-1 HIV-2 LEDGIN LEDGF small molecule inhibitor
Länkar:	https://journals.asm.org/doi/10.1128/spectrum.01699-25
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