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Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Abstract Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost‐effective strategy of including sub‐threshold GWAS (subGWAS) loci (i.e., 5 × 10−8 < P ≤ 10−6) in analysis is explored to increase the inference power of novel pathways. A total of...

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Principais autores: Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-10-01
Serier:Advanced Science
Fag:
dendrite development
genetic risk
GWAS
neurodevelopmental
psychiatric disorder
Schizophrenia
Online adgang:https://doi.org/10.1002/advs.202508519
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