Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Abstract Schizophrenia (SCZ) is highly polygenic, and its biological underpinnings remain unclear. In this study, a cost‐effective strategy of including sub‐threshold GWAS (subGWAS) loci (i.e., 5 × 10−8 < P ≤ 10−6) in analysis is explored to increase the inference power of novel pathways. A total of...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-10-01
Colecção:	Advanced Science
Assuntos:	dendrite development genetic risk GWAS neurodevelopmental psychiatric disorder Schizophrenia
Acesso em linha:	https://doi.org/10.1002/advs.202508519
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!