NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Abstract Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid beta (Aβ) toxicity. Pharmacological block of NMDAR subu...

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Autors principals:	Michaela Kerstin Müller, Eric Jacobi, Kenji Sakimura, Roberto Malinow, Jakob von Engelhardt
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-10-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	NMDA receptor Amyloid Beta Alzheimer’s disease GluN2B GluN2A
Accés en línia:	http://link.springer.com/article/10.1186/s40478-018-0611-4
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