Duloxetine ameliorates chronic stress-induced depressive behaviors by normalizing hippocampal SIK2-CRTC1 signaling

IntroductionDuloxetine, a serotonin-norepinephrine reuptake inhibitor, is clinically effective for major depressive disorder, yet the intracellular mechanisms underlying its therapeutic actions remain incompletely understood. The hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcriptio...

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Auteurs principaux:	Hui Xu, Hua Fan, Bo Jiang, E-hui Ding, Peng Hou, Wei-bing Zhu
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-07-01
Collection:	Frontiers in Pharmacology
Sujets:	cAMP response element binding protein (CREB) CREB-regulated transcription co-activator 1 depression duloxetine hippocampus salt-inducible kinase 2
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1836082/full
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