GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway

Abstract Background M2 macrophage polarization is a key driver of lung adenocarcinoma (LUAD) progression, yet its underlying regulatory mechanisms remain unclear. The expression pattern and biological function of the gap junction protein GJB2 in LUAD have not been elucidated to date. Methods TCGA da...

Полное описание

Библиографические подробности

Главные авторы:	Yuanhua Liu, Guanghui Liu, Jingjing Mei, Jia Li, Jiming Si, Yan Kang, Jianjun Jin
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-01-01
Серии:	Respiratory Research
Предметы:	LUAD GJB2 Macrophage polarization cAMP PKA-CREB signaling pathway
Online-ссылка:	https://doi.org/10.1186/s12931-026-03537-1
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