GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway

Abstract Background M2 macrophage polarization is a key driver of lung adenocarcinoma (LUAD) progression, yet its underlying regulatory mechanisms remain unclear. The expression pattern and biological function of the gap junction protein GJB2 in LUAD have not been elucidated to date. Methods TCGA da...

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Detalhes bibliográficos

Principais autores:	Yuanhua Liu, Guanghui Liu, Jingjing Mei, Jia Li, Jiming Si, Yan Kang, Jianjun Jin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Respiratory Research
Assuntos:	LUAD GJB2 Macrophage polarization cAMP PKA-CREB signaling pathway
Acesso em linha:	https://doi.org/10.1186/s12931-026-03537-1
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