Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice

Abstract Beyond cognitive impairment, Alzheimer’s disease (AD) is frequently accompanied by apathy, the most prevalent and burdensome neuropsychiatric symptom (NPS). Apathy significantly impacts AD onset and progression, yet its molecular underpinnings remain unclear. Our previous RNA-sequencing ana...

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Hlavní autoři:	Raisa Monteiro, Jeffrey T. Dunn, Guadalupe Rodriguez, Daniel W. Fisher, Hongxin Dong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
Témata:	Apathy Alzheimer’s Disease Innate immune system Complement pathway Methylphenidate C3ar antagonist
On-line přístup:	https://doi.org/10.1038/s41598-026-49172-0
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