Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice

Abstract Beyond cognitive impairment, Alzheimer’s disease (AD) is frequently accompanied by apathy, the most prevalent and burdensome neuropsychiatric symptom (NPS). Apathy significantly impacts AD onset and progression, yet its molecular underpinnings remain unclear. Our previous RNA-sequencing ana...

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Detalhes bibliográficos

Principais autores:	Raisa Monteiro, Jeffrey T. Dunn, Guadalupe Rodriguez, Daniel W. Fisher, Hongxin Dong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-04-01
Colecção:	Scientific Reports
Assuntos:	Apathy Alzheimer’s Disease Innate immune system Complement pathway Methylphenidate C3ar antagonist
Acesso em linha:	https://doi.org/10.1038/s41598-026-49172-0
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