Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

Summary: Hsp70 is a key molecular chaperone in the protein quality control system to safeguard protein homeostasis in cells. Previous studies have shown that Hsp70 chaperones TDP-43, a pathogenic protein associated with amyotrophic lateral sclerosis (ALS), in nuclear bodies and prevents it from the...

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Detalhes bibliográficos

Principais autores:	Yichen Li, Jinge Gu, Chen Wang, Jiaojiao Hu, Shenqing Zhang, Cong Liu, Shengnan Zhang, Yanshan Fang, Dan Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-06-01
coleção:	iScience
Assuntos:	Cell biology Organizational aspects of cell biology Biophysics Biophysical chemistry
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004222006277
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