Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

Summary: Hsp70 is a key molecular chaperone in the protein quality control system to safeguard protein homeostasis in cells. Previous studies have shown that Hsp70 chaperones TDP-43, a pathogenic protein associated with amyotrophic lateral sclerosis (ALS), in nuclear bodies and prevents it from the...

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Bibliografische Detailangaben

Hauptverfasser:	Yichen Li, Jinge Gu, Chen Wang, Jiaojiao Hu, Shenqing Zhang, Cong Liu, Shengnan Zhang, Yanshan Fang, Dan Li
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2022-06-01
Schriftenreihe:	iScience
Schlagworte:	Cell biology Organizational aspects of cell biology Biophysics Biophysical chemistry
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004222006277
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