N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes

Abstract Background Microglia play a crucial role in brain development and repair by facilitating processes such as synaptic pruning and debris clearance. They can be activated in response to various stimuli, leading to either pro-inflammatory or anti-inflammatory responses associated with specific...

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Hauptverfasser:	Federica Felice, Pamela De Falco, Martina Milani, Serena Castelli, Antonella Ragnini-Wilson, Giacomo Lazzarino, Nadia D’Ambrosi, Fabio Ciccarone, Maria Rosa Ciriolo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-11-01
Schriftenreihe:	Cell Communication and Signaling
Schlagworte:	Microglial polarization NAA Anti-inflammatory response Oxidative metabolism Lipid turnover Histone deacetylases
Online-Zugang:	https://doi.org/10.1186/s12964-024-01947-6
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