Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions

Abstract The FGF/MEK/ERK and Wnt/β-catenin signaling pathways have previously been proved to regulate mouse embryonic stem cell (mESCs) function. However, the relationships between these two pathways, especially their different functions on proliferation and pluripotency of mESCs, were rarely mentio...

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Главные авторы:	Tong Zhang, Huanyun Chen, Yiran Zhou, Wanghong Dong, Haibo Cai, Wen-Song Tan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	SpringerOpen 2019-04-01
Серии:	Bioresources and Bioprocessing
Предметы:	mESCs FGF/MEK/ERK pathway Wnt/β-catenin pathway Small molecule regulator In vitro proliferation
Online-ссылка:	http://link.springer.com/article/10.1186/s40643-019-0249-5
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