Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular diseases. In this study, the potential of Lgr6 to counteract press...

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Autori principali:	Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-06-01
Serie:	Advanced Science
Soggetti:	cardiac hypertrophy Lgr6 metabolic reprogramming PPARα USP4
Accesso online:	https://doi.org/10.1002/advs.202417597
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