Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2

FcγR activity underpins the role of antibodies in both protective immunity and auto-immunity and importantly, the therapeutic activity of many monoclonal antibody therapies. Some monoclonal anti-FcγR antibodies activate their receptors, but the properties required for cell activation are not well de...

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Bibliografiske detaljer

Principais autores:	Bruce D. Wines, Halina M. Trist, Sandra Esparon, Rachael E. Impey, Graham A. Mackay, Robert K. Andrews, Tatiana P. Soares da Costa, Geoffrey A. Pietersz, Ross I. Baker, P. Mark Hogarth
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-10-01
Serier:	Frontiers in Immunology
Fag:	Fc receptor IgG FcγRIIa effector function antibody dependent cellular cytotoxicity (ADCC) mAb - monoclonal antibody
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.666813/full
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