Strong <italic toggle="yes">In Vivo</italic> Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

ABSTRACT Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro. To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Hongping Jin, Yifan Sun, Dongsheng Li, Min-Hsuan Lin, Mary Lor, Lina Rustanti, David Harrich
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology 2019-08-01
Sarja:	mBio
Aiheet:	Nullbasic animal models antiviral agents gene transfer human immunodeficiency virus
Linkit:	https://journals.asm.org/doi/10.1128/mBio.01769-19
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