Strong <italic toggle="yes">In Vivo</italic> Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

ABSTRACT Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro. To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4...

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Bibliographic Details

Main Authors:	Hongping Jin, Yifan Sun, Dongsheng Li, Min-Hsuan Lin, Mary Lor, Lina Rustanti, David Harrich
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2019-08-01
Series:	mBio
Subjects:	Nullbasic animal models antiviral agents gene transfer human immunodeficiency virus
Online Access:	https://journals.asm.org/doi/10.1128/mBio.01769-19
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