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Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the “obesity paradox”

IntroductionThe incidence of obesity, a condition characterized by systemic chronic inflammation, has reached pandemic proportions and is a poor prognostic factor in many pathologic states. However, its role on immune parameters has been diverse and at times contradictory. We have previously demonst...

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Principais autores: Logan V. Vick, Craig P. Collins, Lam T. Khuat, Ziming Wang, Cordelia Dunai, Ethan G. Aguilar, Kevin Stoffel, Sai Yendamuri, Randall Smith, Sarbajit Mukherjee, Joseph Barbi, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2023-01-01
叢編:Frontiers in Immunology
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在線閱讀:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012016/full
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