Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Many genetic variants identified in genome-wide association studies are associated with gene expression. Here, Porcu et al. propose a transcriptome-wide summary statistics-based Mendelian randomization approach (TWMR) that, applied to 43 human traits, uncovers hundreds of previously unreported gene–...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-019-10936-0 |
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