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Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases

The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and diseases.

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Auteurs principaux: Marie C. Sadler, Chiara Auwerx, Kaido Lepik, Eleonora Porcu, Zoltán Kutalik
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2022-12-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-022-35196-3
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