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MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling

Abstract Background Histone epigenetic modification disorder is an important predisposing factor for the occurrence and development of many cancers, including colorectal cancer (CRC). The role of MYSM1, a metalloprotease that deubiquitinates monoubiquitinated histone H2A, in colorectal cancer was id...

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Principais autores: Xu Chen, Wei Wang, Yufang Li, Yi Huo, Han Zhang, Fan Feng, Wenjin Xi, Tianze Zhang, Jinjian Gao, Fan Yang, Siyi Chen, Angang Yang, Tao Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-10-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
MYSM1
Colorectal cancer
EMT
miR-200
PI3K/AKT
Online adgang:https://doi.org/10.1186/s13046-021-02106-2
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