Oct4 cooperates with c-Myc to improve mesenchymal-to-endothelial transition and myocardial repair of cardiac-resident mesenchymal stem cells

Abstract Background Cardiac-resident mesenchymal stem cells (cMSCs) can exhibit fibrotic, proinflammatory, and proangiogenic phenotype in response to myocardial ischemia (Isch). How their phenotypic fate decisions are determined remains poorly understood. Here, we demonstrate that the cooperation of...

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Detalhes bibliográficos

Principais autores:	Lan Zhao, Jianshuo Wang, Pengzhen Wang, Zhanyu Deng, Jin Cui, Weiguang Huang, Shaoheng Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-09-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Myocardial Infarct Angiogenesis Mesenchymal stem cells c-Myc Oct4
Acesso em linha:	https://doi.org/10.1186/s13287-022-03120-7
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