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Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase

Abstract Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery. In this study, molecular dynamics si...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Federica Maschietto, Uriel N. Morzan, Florentina Tofoleanu, Aria Gheeraert, Apala Chaudhuri, Gregory W. Kyro, Peter Nekrasov, Bernard Brooks, J. Patrick Loria, Ivan Rivalta, Victor S. Batista
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2023-04-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-37956-1
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