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Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase

Abstract Allosteric drugs have the potential to revolutionize biomedicine due to their enhanced selectivity and protection against overdosage. However, we need to better understand allosteric mechanisms in order to fully harness their potential in drug discovery. In this study, molecular dynamics si...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Federica Maschietto, Uriel N. Morzan, Florentina Tofoleanu, Aria Gheeraert, Apala Chaudhuri, Gregory W. Kyro, Peter Nekrasov, Bernard Brooks, J. Patrick Loria, Ivan Rivalta, Victor S. Batista
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Nature Portfolio 2023-04-01
Цуврал:Nature Communications
Онлайн хандалт:https://doi.org/10.1038/s41467-023-37956-1
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