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CD36-mediated podocyte lipotoxicity promotes foot process effacement

Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte lipotoxicity.

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Principais autores: Hua Wei, Peng Lan, Chen Xue-mei, Jiang XuShun, Hu JianGuo, Jiang Xian-Hong, Xiang Xu, Wan Jiangmin, Long Yingfei, Xiong Jianqiong, Ma Xueyi, Du Xiaogang
Formato: Artigo
Idioma:Inglês
Publicado em: De Gruyter 2024-03-01
coleção:Open Medicine
Assuntos:
cd36
podocyte
foot process effacement
palmitic acid
ros
Acesso em linha:https://doi.org/10.1515/med-2024-0918
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