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The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance

Summary: Circulating cell-free DNA (cfDNA) is a promising molecular biomarker, but its role in severe infection is unclear. Here, we profile cfDNA from sepsis patients and controls, demonstrating a 41-fold increase during disease. Methylation-based deconvolution revealed similar cfDNA compositions i...

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Principais autores: Kiki Cano-Gamez, Patrick Maclean, Masato Inoue, Sakineh Hussainy, Elisabeth Foss, Chloe Wainwright, Hanyu Qin, Stuart McKechnie, Chun-Xiao Song, Julian C. Knight
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-10-01
coleção:Cell Genomics
Assuntos:
cell-free DNA
DNA methylation
epigenetics
epigenomics
fragmentomics
sepsis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666979X25002277
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