Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

We investigated whether DNA methylation and cell‐free DNA (cfDNA) fragmentation patterns can improve circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer. In a cohort of 33 patients, ctDNA detection was performed in a tumor‐agnostic fashion using DNA methylation, cfDNA fragment leng...

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Príomhchruthaitheoirí:	Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Wiley 2025-12-01
Sraith:	Molecular Oncology
Ábhair:	cfDNA cfDNA fragmentomics ctDNA DNA methylation machine learning pancreatic cancer
Rochtain ar líne:	https://doi.org/10.1002/1878-0261.70116
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!