Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

We investigated whether DNA methylation and cell‐free DNA (cfDNA) fragmentation patterns can improve circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer. In a cohort of 33 patients, ctDNA detection was performed in a tumor‐agnostic fashion using DNA methylation, cfDNA fragment leng...

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Detalhes bibliográficos

Principais autores:	Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-12-01
coleção:	Molecular Oncology
Assuntos:	cfDNA cfDNA fragmentomics ctDNA DNA methylation machine learning pancreatic cancer
Acesso em linha:	https://doi.org/10.1002/1878-0261.70116
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